SPPIN - Saints-Pères Paris Institute for the Neurosciences - CNRS UMR 8003
Université Paris Cité
F-75006 Paris
France

Dr. Claire Legay

Professor Emeritus, Université Paris Cité
Team 3 - Biology and physiopathology of the spinal cord

claire.legay@-Code to remove to avoid SPAM-u-paris.fr
+33 1 76 53 42 41, room H345a

Recent Publications

Articles

• Managing surface energy dynamics for enhanced axonal growth: An overview of present and future challenges
  Sénépart O, Legay C, Hamraoui A : Biophysics Reviews, 2025
• The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase–LRP4 receptor complex by agrin at the neuromuscular junction
  Thi Minh Uyen Dao, Susie Barbeau, Julien Messéant, Bruno Della-Gaspera, Tahar Bouceba, Fannie Semprez, Claire Legay, and Alexandre Dobbertin : J Biol Chem, 2023
• Data clustering analysis of scanning ultrafast acoustic experiments. How acoustic and structural properties of a motoneuron are revealed
  Péronne E, Sénépart O, Legay C, Semprez F, Hamraoui A, Belliard L : {Physical Review Applied}, 2022
• Adhesion energy modulation acts as an NGF receptor activator for neuronal differentiation in NGF-free medium
  Sénépart O, Legay C, Hélary C, Hamraoui A : Advanced Materials Interfaces, 2022
• Correlative Imaging of Motoneuronal Cell Elasticity by Pump and Probe Spectroscopy.
  Hamraoui A, Sénépart O, Schneider M, Malaquin S, Péronne E, Becerra L, Semprez F, Legay C, Belliard L : Biophys J, 2021
• AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.
  Karmouch J, Delers P, Semprez F, Soyed N, Areias J, Bélanger G, Ravel-Chapuis A, Dobbertin A, Jasmin BJ, Legay C : Front Mol Neurosci, 2020
• Collagens at the vertebrate neuromuscular junction, from structure to pathologies.
  Legay C, Dobbertin A : Neurosci Lett, 2020
• Building neuromuscular junctions in vitro.
  Barbeau S, Tahraoui-Bories J, Legay C, Martinat C : Development, 2020
• Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ.
  Barbeau S, Desprat R, Eymard B, Martinat C, Lemaitre JM, Legay C : Stem Cell Res, 2020
• Picosecond ultrasounds as elasticity probes in neuron-like cells models
  Viel A, Péronne E, Sénépart O, Becerra L, Legay C, Semprez F, Trichet L, Coradin T, Hamraoui A, Belliard L : Applied Physics Letters, 2019
• Congenital myasthenic syndromes with acetylcholinesterase deficiency, the pathophysiological mechanisms.
  Legay C : Ann N Y Acad Sci, 2018
• Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.
  Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M, Sans N, Legay C, Strochlic L : Development, 2017
• Moving forward with the neuromuscular junction.
  Legay C, Mei L : J Neurochem, 2017
• Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.
  Sigoillot SM, Bourgeois F, Karmouch J, Molgó J, Dobbertin A, Chevalier C, Houlgatte R, Léger J, Legay C : FASEB J, 2016
• A critical and previously unsuspected role for doublecortin at the neuromuscular junction in mouse and human.
  Bourgeois F, Messéant J, Kordeli E, Petit JM, Delers P, Bahi-Buisson N, Bernard V, Sigoillot SM, Gitiaux C, Stouffer M, Francis F, Legay C : Neuromuscul Disord, 2015
• HuR Mediates Changes in the Stability of AChR β-Subunit mRNAs after Skeletal Muscle Denervation.
  Joassard OR, Bélanger G, Karmouch J, Lunde JA, Shukla AH, Chopard A, Legay C, Jasmin BJ : J Neurosci, 2015
• MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.
  Messéant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molgó J, Zytnicki D, Schaeffer L, Legay C, Strochlic L : J Neurosci, 2015
• Developmental consequences of the ColQ/MuSK interactions
  Karmouch J, Dobbertin A, Sigoillot S, Legay C : Chem Biol Interact, 2013
• Wnt4 participates in the formation of vertebrate neuromuscular junction.
  Strochlic L, Falk J, Goillot E, Sigoillot S, Bourgeois F, Delers P, Rouvière J, Swain A, Castellani V, Schaeffer L, Legay C : PLoS One, 2012
• Wnt4 participates in the formation of vertebrate neuromuscular junction
  Strochlic L, Falk J, Goillot E, Sigoillot S, Bourgeois F, Delers P, Rouvière J, Swain A, Castellani V, Schaeffer L, Legay C : PLoS One, 2012
• Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression
  Richard AF, Demignon J, Sakakibara I, Pujol J, Favier M, Strochlic L, Le Grand F, Sgarioto N, Guernec A, Schmitt A, Cagnard N, Huang R, Legay C, Guillet-Deniau I, Maire P : Dev Biol, 2011
• Cholinesterases regulation in the absence of ColQ.
  Sigoillot SM, Bourgeois F, Legay C : Chem Biol Interact, 2010
• ColQ controls postsynaptic differentiation at the neuromuscular junction
  Sigoillot SM, Bourgeois F, Lambergeon M, Strochlic L, Legay C : J Neurosci, 2010
• Identification of cis-acting elements involved in acetylcholinesterase RNA alternative splicing.
  Guerra M, Dobbertin A, Legay C : Mol Cell Neurosci, 2008
• Caractérisation physiopathologique des syndromes myasthéniques congénitaux : l’exemple de mutations dans le gène MUSK
  Chevessier F, Faraut B, Ravel-Chapuis A, Richard P, Gaudon K, Bauché S, Prioleau C, Herbst R, Goillot E, Ioos C, Azulay JP, Attarian S, Leroy JP, Fournier E, Legay C, Schaeffer L, Koenig J, Fardeau M, Eymard B, Pouget J, Hantaï D : J Soc Biol, 2005
• Towards the molecular elucidation of congenital myasthenic syndromes: identification of mutations in MuSK.
  Chevessier F, Faraut B, Ravel-Chapuis A, Richard P, Gaudon K, Bauché S, Prioleau C, Herbst R, Goillot E, Ioos C, Azulay JP, Attarian S, Leroy JP, Fournier E, Legay C, Schaeffer L, Koenig J, Fardeau M, Eymard B, Pouget J, Hantaï D : Acta Myol, 2005
• Acetylcholinesterase and molecular interactions at the neuromuscular junction.
  Guerra M, Cartaud A, Cartaud J, Legay C : Chem Biol Interact, 2005
• Expression of vesicular glutamate transporters, VGLUT1 and VGLUT2, in cholinergic spinal motoneurons.
  Herzog E, Landry M, Buhler E, Bouali-Benazzouz R, Legay C, Henderson CE, Nagy F, Dreyfus P, Giros B, El Mestikawy S : EMBO J, 2004
• MUSK, a new target for mutations causing congenital myasthenic syndrome.
  Chevessier F, Faraut B, Ravel-Chapuis A, Richard P, Gaudon K, Bauché S, Prioleau C, Herbst R, Goillot E, Ioos C, Azulay JP, Attarian S, Leroy JP, Fournier E, Legay C, Schaeffer L, Koenig J, Fardeau M, Eymard B, Pouget J, Hantaï D : Hum Mol Genet, 2004
• MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.
  Cartaud A, Strochlic L, Guerra M, Blanchard B, Lambergeon M, Krejci E, Cartaud J, Legay C : J Cell Biol, 2004
• Why so many forms of acetylcholinesterase?
  Legay C : Microsc Res Tech, 2000
• Fractionation of gliadin hydrolysates in water-ethanol by ultrafiltration with modified or unmodified membranes.
  Bérot S, Chaufer B, Basso Y, Legay C, Popineau Y : Biotechnol Bioeng, 1999
• Differences in expression of acetylcholinesterase and collagen Q control the distribution and oligomerization of the collagen-tailed forms in fast and slow muscles.
  Krejci E, Legay C, Thomine S, Sketelj J, Massoulié J : J Neurosci, 1999
• Stability and secretion of acetylcholinesterase forms in skeletal muscle cells.
  Legay C, Mankal FA, Massoulié J, Jasmin BJ : J Neurosci, 1999
• The polymorphism of acetylcholinesterase: post-translational processing, quaternary associations and localization.
  Massoulié J, Anselmet A, Bon S, Krejci E, Legay C, Morel N, Simon S : Chem Biol Interact, 1999
• Acetylcholinesterase: C-terminal domains, molecular forms and functional localization.
  Massoulié J, Anselmet A, Bon S, Krejci E, Legay C, Morel N, Simon S : J Physiol Paris, 1998
• The mammalian gene of acetylcholinesterase-associated collagen.
  Krejci E, Thomine S, Boschetti N, Legay C, Sketelj J, Massoulié J : J Biol Chem, 1997
• Biosynthesis and integration of acetylcholinesterase in the cholinergic synapse.
  Massoulié J, Legay C, Anselmet A, Krejci E, Coussen F, Bon S : Prog Brain Res, 1996
• Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and focalization.
  Legay C, Huchet M, Massoulié J, Changeux JP : Eur J Neurosci, 1995
• Anatomical analysis of the neurons expressing the acetylcholinesterase gene in the rat brain, with special reference to the striatum.
  Bernard V, Legay C, Massoulie J, Bloch B : Neuroscience, 1995
• Selection of cytotoxic responses to maitotoxin and okadaic acid and evaluation of toxicity of dinoflagellate extracts.
  Fessard V, Diogène G, Dubreuil A, Quod JP, Durand-Clément M, Legay C, Puiseux-Dao S : Nat Toxins, 1994
• Expression of a cDNA encoding the glycolipid-anchored form of rat acetylcholinesterase.
  Legay C, Bon S, Massoulié J : FEBS Lett, 1993
• Influence of matricial molecules on growth and differentiation of entrapped chondrocytes.
  Ramdi H, Legay C, Lièvremont M : Exp Cell Res, 1993
• Cloning and expression of a rat acetylcholinesterase subunit: generation of multiple molecular forms and complementarity with a Torpedo collagenic subunit.
  Legay C, Bon S, Vernier P, Coussen F, Massoulié J : J Neurochem, 1993
• Primary structure of a collagenic tail peptide of Torpedo acetylcholinesterase: co-expression with catalytic subunit induces the production of collagen-tailed forms in transfected cells.
  Krejci E, Coussen F, Duval N, Chatel JM, Legay C, Puype M, Vandekerckhove J, Cartaud J, Bon S, Massoulié J : EMBO J, 1991
• Complex alternative splicing of acetylcholinesterase transcripts in Torpedo electric organ; primary structure of the precursor of the glycolipid-anchored dimeric form.
  Sikorav JL, Duval N, Anselmet A, Bon S, Krejci E, Legay C, Osterlund M, Reimund B, Massoulié J : EMBO J, 1988
• Development of 5-hydroxytryptamine-like immunoreactive neurones in cultures of the myenteric plexus from the guinea-pig caecum.
  Saffrey MJ, Legay C, Burnstock G : Brain Res, 1984
• Coexistence of immunoreactive substance P and serotonin in neurones of the gut.
  Legay C, Saffrey MJ, Burnstock G : Brain Res, 1984
• 5-HT metabolism in the intestinal wall of the rat-II. The nerves plexuses-interactions between 5-HT containing cells.
  Legay C, Faudon M, Héry F, Ternaux JP : Neurochem Int, 1983
• Amines and choline acetyltransferase in rat intestine.
  Legay C, Faudon M, Ternaux JP : Neurochem Int, 1983
• 5-HT metabolism in the intestinal wall of the rat-I. The mucosa.
  Legay C, Faudon M, Héry F, Ternaux JP : Neurochem Int, 1983
• Regulatory aspects of 5-HT biosynthesis in the intestinal tract of the rat.
  Legay C, Ternaux JP : Scand J Gastroenterol Suppl, 1982
• 5-HT metabolism in the intestinal wall of the rabbit.
  Ternaux JP, Gonella J, Legay C, Faudon M, Barrit MC, Héry F : J Physiol Paris, 1981

Chapters

• De la molécule au neurone
  Claire Legay : extracted from La cognition, Du neurone à la société Thérèse Collins, Daniel Andler, Catherine Tallon-B - Folio, ISBN:2072764378, 2023
• De la molécule au neurone
  Claire Legay : extracted from La cognition, Du neurone à la société Thérèse Collins, Daniel Andler, Catherine Tallon-B - Folio, ISBN:2072764378, 2023

Speech communications / proceedings

• Extracting Weak Signal with the Help of Data Clustering: Application to Motoneuron Adhesion
  Emmanuel Péronne, Sophie Malaquin, Loic Becerra, Laurent Belliard, Ahmed Hamraoui, Claire Legay, Fannie Semprez : Forum Acusticum, Lyon, France, 2020
• Picosecond ultrasounds as elasticity probes in neuron-like cells models.
  Laurent Belliard, Alexis Viel, Emmanuel Péronne, Océane Sénépart, Loic Becerra, Claire Legay, Fannie Semprez, Lea Trichet, Thibaud Coradin, Ahmed Hamraoui : Forum Acusticum, Lyon, France, 2020

Patents

• la pré-stimulation électrique d’un dispositif implantable pour la réparation du nerf
  Ahmed HAMRAOUI, Océane SENEPART, Claire LEGAY, Hafsa ER-ROUASSI, Richard Junior AMEDZROVI AGBESI : Patent # : DSO2025028091, 2025
• Nerve repair implant: International application
  A Hamraoui, O Sénépart, C Legay : Patent # : WO2024/241069, 2024